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1996-03-09
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Document 0073
DOCN M9650073
TI Cytomegalovirus optic neuritis: characteristics, therapy and survival.
DT 9605
AU Mansor AM; Li HK; Department of Ophthamology, University of Texas
Medical Branch,; Galveston 77555-0787, USA.
SO Ophthalmologica. 1995;209(5):260-6. Unique Identifier : AIDSLINE
MED/96141238
AB Little is known about the natural history of cytomegalovirus (CMV) optic
neuritis in the acquired immunodeficiency syndrome. We analyzed the
clinical course of CMV optic neuritis in 30 consecutive subjects (35
eyes), and compared the survival of patients with CMV optic neuritis to
that of a group having CMV retinitis alone, with both groups matched for
ganciclovir therapy. Four untreated eyes had a median final visual
acuity of no light perception. The median final visual acuity was 20/100
in treated subjects with a mean follow-up of 6.6 months. Following
ganciclovir treatment, 2 eyes showed visual improvement, 17 eyes had
unchanged visual acuity, and 12 eyes had marked drop in acuity. Relapse
occurred in 4 subjects maintained on single-dose ganciclovir, and was
controlled on double-dose ganciclovir. Survival was similar in the group
of CMV retinitis alone versus the group of CMV optic neuritis with
retinitis. Early recognition and therapy of CMV optic neuritis protects
against irreversible visual loss. CMV optic neuritis does not carry a
worse prognosis for survival than CMV retinitis alone.
DE Adult Antiviral Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE
AIDS-Related Opportunistic Infections/DRUG THERAPY/*ETIOLOGY/ MORTALITY
Comparative Study Cytomegalovirus Infections/DRUG
THERAPY/*ETIOLOGY/MORTALITY Cytomegalovirus Retinitis/DRUG
THERAPY/ETIOLOGY/MORTALITY Eye Infections, Viral/DRUG
THERAPY/*ETIOLOGY/MORTALITY Female Follow-Up Studies Fundus Oculi
Ganciclovir/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Human Male
Middle Age Optic Nerve/PATHOLOGY Optic Neuritis/DRUG
THERAPY/MORTALITY/*VIROLOGY Prospective Studies Recurrence
Retinitis/PATHOLOGY Retrospective Studies Survival Rate Visual Acuity
Visual Fields JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).